SiNAPS by Corticale
SiNAPS by Corticale
The most advanced active neural probes technology for brain research in neuroscience
SiNAPS by Corticale
The most advanced active neural probes technology for brain research in neuroscience
SiNAPS probe is the new and most advanced tool for electrophysiological experiment for neuroscientist. It applies to any experimental need, in a wide range of animal models and is compatible with most of the standard hardware and data analysis tool.
Making easy the brain complexity
SiNAPS probe is the new and most advanced tool for electrophysiological experiment for neuroscientist. It applies to any experimental need, in a wide range of animal models and is compatible with most of the standard hardware and data analysis tool.
Full band recording (Local Field and Action Potentials)
Full band recording (Local Field and Action Potentials)
20 kHz sampling frequency from each channel
20 kHz sampling frequency from each channel
<8µV RMS noise amplifiers in AP band
<8µV RMS noise amplifiers in AP band
14 x 14 µm Ti/Pt electrode interface
14 x 14 µm Ti/Pt electrode interface
30 µm electrode pitch
30 µm electrode pitch
Minimal wiring
Minimal wiring
Internal on-probe reference
Internal on-probe reference
Whole array readout: no need for channel pre-selection
Whole array readout: no need for channel pre-selection
Corticale provides 5 different SiNAPS probe layouts ranging from 256 to 1024 simultaneously recording electrodes arranged in high-density array on one or multiple shank. Each electrode has its own independent low-noise amplifier making useless any additional external amplification electronic. Thanks to its on-shank time division multiplexing circuitry SiNAPS probes requires a very low number of interconnecting wires (in a ratio of 1 every 32 channels) to transmit the neural data to the digital acquisition system, thus enabling extremely compact and lightweight packaging, ideal for small animals.
High-density neural data collected from SiNAPS probes enable neuroscientist in mapping, at the single cell, wide brain circuits with an unprecedented spatiotemporal resolution, without the need of complicated procedures and expensive tools. This advancing not only the brain understanding but also reducing the number of subjects needed to achieve statistically significant results compared with standard low-channel count silicon probes.
Recording from 8-shanks 1024 channels SiNAPS probe of mouse hippocampus
(fullband traces and spike raster plot)
Capture the brain dynamics
The complex mechanisms that regulate brain function often arise from extensive neural networks that synergistically generate neural dynamics. These dynamics gain true meaning only when the collective activity of these circuits can be accurately captured.
This is why we have designed and developed high-density neural probes that, compared to any competing solution, offer neuroscientists community with the most advanced electrophysiological tool capable of recording the bioelectrical activity of entire neural circuits with unmatched spatiotemporal resolution.
Multishanks recording
from 16 channels
Multishanks recoding
from 384 channels
SiNAPS
Multishanks recording
from 1024 channels
One technology, multiple layouts
Corticale probes are all based on SiNAPS technology whose allows for the realization of active CMOS-based devices capable of recording simultaneously from all the available electrodes present on the probe, by guarantee the following specifications:
One technology, multiple layouts
Corticale probes are all based on SiNAPS technology whose allows for the realization of active CMOS-based devices capable of recording simultaneously from all the available electrodes present on the probe, by guarantee the following specifications:
Model 1
Model 1
Channels: 256
Shanks: 1
Shanks Size (WxL): 88x5900
Active Area: 3865
Shanks Spacing: -
Array Layout: 2 columns
Model 1
Model 2
Channels: 1024
Shanks: 4
Shanks Size (WxL): 88x5900
Active Area: 3865
Shanks Spacing: 560
Array Layout: 2 columns
Model 2
Model 3
Channels: 512
Shanks: 1
Shanks Size (WxL): 88x9700
Active Area: 7750
Shanks Spacing: -
Array Layout: 2 columns
Model 3
Model 4
Channels: 1024
Shanks: 8
Shanks Size (WxL): 88x5050
Active Area: 1925
Shanks Spacing: 300
Array Layout: 2 Columns
Model 4
Model 5
Channels: 512
Shanks: 1
Shanks Size (WxL): 88x6900
Active Area: 3870
Shanks Spacing: -
Array Layout: 4 Columns
Model 5
Probe Model
Channels
Shanks Numb.
Shank Size (WxL)
Active Area
Shank Spacing
Array Layout
Model 1
256
1
88 x 5900
3865
-
2 columns
Model 2
1024
4
88 x 5900
3865
560
2 columns
Model 3
512
1
88 x 9700
7750
-
2 columns
Model 4
1024
8
88 x 5050
1925
300
2 columns
Model 5
512
1
155 x 6900
3870
-
4 columns
Dimensions are expressed in micrometers
Our SiNAPS probes are compatible and provided by leading neurotech companies
Our SiNAPS probes are compatible and provided by leading neurotech companies
SiNAPS probes data are compatible with most of the standard data analysis tools such as Kilosort, Phy and SpikeInterface.
Voices from the field
" Understanding neural circuits is a problem of both depth and breadth, the SiNAPS probe provides true 1024 channels of simultaneous recording. With its configurable 4 or 8 shanks, it can record from a large volume of brain structures, such as the neocortex, hippocampus, striatum, and thalamus, allowing monitoring of both mesoscopic local field potentials and single neurons at an unprecedented scale. ”
-György Buzsáki, M.D., Ph.D., Biggs Professor of Neural Sciences at the NYU Neuroscience Institute, Langone Medical Center.
“These amazing probes give an unprecedented insight into cortical function. We have been able to record from many thousands of cells in awake behaving monkey, throughout the cortical depth and into the bank of the central sulcus. They are easy to use, and mark a considerable refinement because experimental sessions can be shortened whilst actually gathering more data. I especially appreciate the ability to record from all contacts at once, meaning we don’t have to make critical decisions on the fly about which channels to choose.”
-Stuart Baker, Professor of Movement Neuroscience
Faculty of Medical Sciences, Newcastle University
Many laboratories around the world have already chosen to use our technology to advance their research
SiNAPS probe is the new and most advanced tool for electrophysiological experiment for neuroscientist. It applies to any experimental need, in a wide range of animal models and is compatible with most of the standard hardware and data analysis tool.
Making easy the brain complexity
Full band recording (Local Field and Action Potentials)
20 kHz sampling frequency from each channel
<8µV RMS noise amplifiers in AP band
14 x 14 µm Ti/Pt electrode interface
30 µm electrode pitch
Minimal wiring
Internal on-probe reference
Whole array readout: no need for channel pre-selection
Corticale provides 5 different SiNAPS probe layouts ranging from 256 to 1024 simultaneously recording electrodes arranged in high-density array on one or multiple shank. Each electrode has its own independent low-noise amplifier making useless any additional external amplification electronic. Thanks to its on-shank time division multiplexing circuitry SiNAPS probes requires a very low number of interconnecting wires (in a ratio of 1 every 32 channels) to transmit the neural data to the digital acquisition system, thus enabling extremely compact and lightweight packaging, ideal for small animals.
High-density neural data collected from SiNAPS probes enable neuroscientist in mapping, at the single cell, wide brain circuits with an unprecedented spatiotemporal resolution, without the need of complicated procedures and expensive tools. This advancing not only the brain understanding but also reducing the number of subjects needed to achieve statistically significant results compared with standard low-channel count silicon probes.
Recording from 8-shanks 1024 channels SiNAPS probe of mouse hippocampus
(fullband traces and spike raster plot)
Capture the brain dynamics
The complex mechanisms that regulate brain function often arise from extensive neural networks that synergistically generate neural dynamics. These dynamics gain true meaning only when the collective activity of these circuits can be accurately captured.
This is why we have designed and developed high-density neural probes that, compared to any competing solution, offer neuroscientists community with the most advanced electrophysiological tool capable of recording the bioelectrical activity of entire neural circuits with unmatched spatiotemporal resolution.
Multishanks recording
from 16 channels
Multishanks recoding
from 384 channels
SiNAPS
Multishanks recording
from 1024 channels
One technology, multiple layouts
Corticale probes are all based on SiNAPS technology whose allows for the realization of active CMOS-based devices capable of recording simultaneously from all the available electrodes present on the probe, by guarantee the following specifications:
Model 1
Model 1
Model 2
Model 2
Model 3
Model 3
Model 4
Model 4
Model 5
Model 5
Probe Model
Channels
Shanks Numb.
Shank Size (WxL)
Active Area
Shank Spacing
Array Layout
Model 1
256
1
88 x 5900
3865
-
2 columns
Model 2
1024
4
88 x 5900
3865
560
2 columns
Model 3
512
1
88 x 9700
7750
-
2 columns
Model 4
1024
8
88 x 5050
1925
300
2 columns
Model 5
512
1
155 x 6900
3870
-
4 columns
Dimensions are expressed in micrometers
Our SiNAPS probes are compatible and provided by leading neurotech companies
SiNAPS probes data are compatible with most of the standard data analysis tools such as Kilosort, Phy and SpikeInterface.
Voices from the field
" Understanding neural circuits is a problem of both depth and breadth, the SiNAPS probe provides true 1024 channels of simultaneous recording. With its configurable 4 or 8 shanks, it can record from a large volume of brain structures, such as the neocortex, hippocampus, striatum, and thalamus, allowing monitoring of both mesoscopic local field potentials and single neurons at an unprecedented scale. ”
-György Buzsáki, M.D., Ph.D., Biggs Professor of Neural Sciences at the NYU Neuroscience Institute, Langone Medical Center.
“These amazing probes give an unprecedented insight into cortical function. We have been able to record from many thousands of cells in awake behaving monkey, throughout the cortical depth and into the bank of the central sulcus. They are easy to use, and mark a considerable refinement because experimental sessions can be shortened whilst actually gathering more data. I especially appreciate the ability to record from all contacts at once, meaning we don’t have to make critical decisions on the fly about which channels to choose.”
-Stuart Baker, Professor of Movement Neuroscience
Faculty of Medical Sciences, Newcastle University
Many laboratories around the world have already chosen to use our technology to advance their research
Progetto cofinanziato con risorse del PR FESR Liguria 2021/2027
Programma Regionale PR FESR Liguria 2021/2027 – Obiettivo Specifico 1.2. “Permettere ai cittadini, alle impese, alle organizzazioni di ricerca e alle autorità pubbliche di cogliere i vantaggi della digitalizzazione” – Azione 1.2.3 “Sostenere l’introduzione di pratiche e tecnologie digitali nelle imprese” – Bando “Supporto allo sviluppo di progetti di digitalizzazione nelle micro, piccole e medie imprese” – Anno 2024.
Via Pietro Chiesa 9
16149 Genova, Italy
Phone: +39 010 8595211
Email: info@corticale.com
Privacy Policy
Cookie Policy
Grants & Incentives
Quality Policy
Registered Office: Via Pietro Chiesa 9 - 16149 Genova (GE) | Branch: Via Porta Tenaglia 1 Milano (MI)
Progetto cofinanziato con risorse del PR FESR Liguria 2021/2027
Programma Regionale PR FESR Liguria 2021/2027 – Obiettivo Specifico 1.2. “Permettere ai cittadini, alle impese, alle organizzazioni di ricerca e alle autorità pubbliche di cogliere i vantaggi della digitalizzazione” – Azione 1.2.3 “Sostenere l’introduzione di pratiche e tecnologie digitali nelle imprese” – Bando “Supporto allo sviluppo di progetti di digitalizzazione nelle micro, piccole e medie imprese” – Anno 2024.
Via Pietro Chiesa 9
16149 Genova, Italy
Phone: +39 010 8595211
Email: info@corticale.com
Privacy Policy
Cookie Policy
Grants & Incentives
Quality Policy
Registered Office: Via Pietro Chiesa 9 - 16149 Genova (GE) | Branch: Via Porta Tenaglia 1 Milano (MI)
Progetto cofinanziato con risorse del PR FESR Liguria 2021/2027
Programma Regionale PR FESR Liguria 2021/2027 – Obiettivo Specifico 1.2. “Permettere ai cittadini, alle impese, alle organizzazioni di ricerca e alle autorità pubbliche di cogliere i vantaggi della digitalizzazione” – Azione 1.2.3 “Sostenere l’introduzione di pratiche e tecnologie digitali nelle imprese” – Bando “Supporto allo sviluppo di progetti di digitalizzazione nelle micro, piccole e medie imprese” – Anno 2024.
Via Pietro Chiesa 9
16149 Genova, Italy
Phone: +39 010 8595211
Email: info@corticale.com
Privacy Policy
Cookie Policy
Grants & Incentives
Quality Policy
Registered Office: Via Pietro Chiesa 9 - 16149 Genova (GE) Branch: Via Porta Tenaglia 1 Milano (MI)
^