SiNAPS by Corticale
SiNAPS by Corticale
The most advanced technology for active neural probes in neuroscience brain research
SiNAPS by Corticale
The most advanced technology for active neural probes in neuroscience brain research
Circuit-level understanding is central to neuroscience: behavior and computation emerge from interactions across populations of neurons, not isolated signals. Higher-density, simultaneous recordings provide the resolution needed to map dynamics across networks and reduce uncertainty in interpretation.
SiNAPS enables up to 1,024-channel simultaneous electrophysiology, adaptable to diverse experimental setups and compatible with standard acquisition and analysis pipelines.
Making easy the brain complexity
SiNAPS enables up to 1,024-channel simultaneous electrophysiology, adaptable to diverse experimental setups and compatible with standard acquisition and analysis pipelines.
Circuit-level understanding is central to neuroscience: behavior and computation emerge from interactions across populations of neurons, not isolated signals. Higher-density, simultaneous recordings provide the resolution needed to map dynamics across networks and reduce uncertainty in interpretation.
SiNAPS enables up to 1,024-channel simultaneous electrophysiology, adaptable to diverse experimental setups and compatible with standard acquisition and analysis pipelines.
SEM image of a Model 5 SiNAPS probe.
Low-noise whole array readout: plug and play,
no channel pre-selection.Full-band recordings (0.1Hz- 5kHz) at 20 kHz: capturing
both low-frequency LFP dynamics and high-frequency
spiking activity in the same dataset.Single-cell resolution: 14 × 14 μm electrodes with a 30μm
pitch for high-density recordings, supporting robust
single-unit identification for circuit-level analysis.
Corticale offers SiNAPS probes in multiple layouts and shank configurations, with up to 1,024 simultaneously recording electrodes arranged in high-density arrays. Low-noise amplification at each electrode site and on-shank time-division multiplexing reduce external electronics and minimize the number of interconnects needed to stream data to the acquisition system. The result is a compact, lightweight probe platform designed to support stable, high-density recordings across animal models and experimental constraints.
High-density datasets from SiNAPS enable neuroscientists to isolate single units and map circuit interactions across broader networks, helping bridge activity from local microcircuits to larger-scale structures. Different configurations adapt seamlessly to a wide range of applications, from targeted recordings in deep brain regions to detailed circuit studies across macrostructures. By capturing more information per experiment, SiNAPS can also increase statistical power and reduce the number of animals needed compared with low-channel-count approaches.
Recording from 8-shanks 1024 channels SiNAPS probe of mouse hippocampus
(fullband traces and spike raster plot)
Capture the brain dynamics
The complex mechanisms that regulate brain function often emerge from extensive neural networks that work together to generate neural dynamics. These dynamics gain true meaning only when the collective activity of these circuits can be accurately captured.
That’s why we designed and developed high-density neural probes that, compared with any competing solution, provide the neuroscience community with an advanced electrophysiology tool capable of recording the bioelectrical activity of entire neural circuits with unmatched spatiotemporal resolution.
Multishanks recording
from 16 channels
Multishanks recoding
from 384 channels
SiNAPS
Multishanks recording
from 1024 channels
One technology, multiple layouts
Corticale probes are based on SiNAPS technology, which enables the development of active CMOS devices capable of recording simultaneously from all electrodes on the probe, while ensuring the following specifications:
256 simultaneously recording electrodes arranged in a two-column layoutSingle shankActive Area: 3865µm²
Model 1
1024 simultaneously recording electrodes arranged in a two-column layout
4 shanks with 560 µm inter-shank spacing
Active Area: 3865µm
²per shank
Model 2
512 simultaneously recording electrodes arranged in a two-column layout
Single shank
Active Area: 7750µm
²
Model 3
1024 simultaneously recording electrodes arranged in a two-column layout
8 shanks with 300µm inter-shank spacin
Active Area: 1925µm
²per shank
Model 4
512 simultaneously recording electrodes arranged in a four-column layout
Single shank
Active Area: 3870µm
²
Model 5
Hover a probe to see details.
The Corticale Ecosystem
SiNAPS probes are only as powerful as the workflow around them.
Corticale provides an end-to-end ecosystem: from in vivo data acquisition with our probes, through dedicated hardware, to analysis.
One technology, multiple layouts
Corticale probes are based on SiNAPS technology, which enables the development of active CMOS devices capable of recording simultaneously from all electrodes on the probe, while ensuring the following specifications:
256 simultaneously recording electrodes arranged in a two-column layoutSingle shankActive Area: 3865µm²
Model 1
1024 simultaneously recording electrodes arranged in a two-column layout
4 shanks with 560 µm inter-shank spacing
Active Area: 3865µm
²per shank
Model 2
512 simultaneously recording electrodes arranged in a two-column layout
Single shank
Active Area: 7750µm
²
Model 3
1024 simultaneously recording electrodes arranged in a two-column layout
8 shanks with 300µm inter-shank spacin
Active Area: 1925µm
²per shank
Model 4
512 simultaneously recording electrodes arranged in a four-column layout
Single shank
Active Area: 3870µm
²
Model 5
Hover a probe to see details.
The Corticale Ecosystem
SiNAPS probes are only as powerful as the workflow around them.
Corticale provides an
end-to-end ecosystem: from in vivo data acquisition with our probes, through dedicated hardware, to analysis.
Voices from the field
" Understanding neural circuits is a problem of both depth and breadth, the SiNAPS probe provides true 1024 channels of simultaneous recording. With its configurable 4 or 8 shanks, it can record from a large volume of brain structures, such as the neocortex, hippocampus, striatum, and thalamus, allowing monitoring of both mesoscopic local field potentials and single neurons at an unprecedented scale. ”
-György Buzsáki, M.D., Ph.D., Biggs Professor of Neural Sciences at the NYU Neuroscience Institute, Langone Medical Center.
“These amazing probes give an unprecedented insight into cortical function. We have been able to record from many thousands of cells in awake behaving monkey, throughout the cortical depth and into the bank of the central sulcus. They are easy to use, and mark a considerable refinement because experimental sessions can be shortened whilst actually gathering more data. I especially appreciate the ability to record from all contacts at once, meaning we don’t have to make critical decisions on the fly about which channels to choose.”
-Stuart Baker, Professor of Movement Neuroscience
Faculty of Medical Sciences, Newcastle University
Our SiNAPS probes are compatible and provided by leading neurotech companies
Our SiNAPS probes are compatible and provided by leading neurotech companies
SiNAPS probes data are compatible with most of the standard data analysis tools such as Kilosort, Phy and SpikeInterface.
Many laboratories around the world have already chosen to use our technology to advance their research
Circuit-level understanding is central to neuroscience: behavior and computation emerge from interactions across populations of neurons, not isolated signals. Higher-density, simultaneous recordings provide the resolution needed to map dynamics across networks and reduce uncertainty in interpretation.
SiNAPS enables up to 1,024-channel simultaneous electrophysiology, adaptable to diverse experimental setups and compatible with standard acquisition and analysis pipelines.
Making easy the brain complexity
SiNAPS enables up to 1,024-channel simultaneous electrophysiology, adaptable to diverse experimental setups and compatible with standard acquisition and analysis pipelines.
Circuit-level understanding is central to neuroscience: behavior and computation emerge from interactions across populations of neurons, not isolated signals. Higher-density, simultaneous recordings provide the resolution needed to map dynamics across networks and reduce uncertainty in interpretation.
SiNAPS enables up to 1,024-channel simultaneous electrophysiology, adaptable to diverse experimental setups and compatible with standard acquisition and analysis pipelines.
SEM image of a Model 5 SiNAPS probe.
Low-noise whole array readout: plug and play,
no channel pre-selectionFull-band recordings (0.1Hz- 5kHz) at 20 kHz: capturing both
low-frequency LFP dynamics and high-frequency
spiking activity in the same dataset.Single-cell resolution: 14 × 14 μm electrodes with a 30μm pitch
for high-density recordings, supporting robust
single-unit identification for circuit-level analysis.
Corticale offers SiNAPS probes in multiple layouts and shank configurations, with up to 1,024 simultaneously recording electrodes arranged in high-density arrays. Low-noise amplification at each electrode site and on-shank time-division multiplexing reduce external electronics and minimize the number of interconnects needed to stream data to the acquisition system. The result is a compact, lightweight probe platform designed to support stable, high-density recordings across animal models and experimental constraints.
High-density datasets from SiNAPS enable neuroscientists to isolate single units and map circuit interactions across broader networks, helping bridge activity from local microcircuits to larger-scale structures. Different configurations adapt seamlessly to a wide range of applications, from targeted recordings in deep brain regions to detailed circuit studies across macrostructures. By capturing more information per experiment, SiNAPS can also increase statistical power and reduce the number of animals needed compared with low-channel-count approaches.
Recording from 8-shanks 1024 channels SiNAPS probe of mouse hippocampus
(fullband traces and spike raster plot)
Capture the brain dynamics
The complex mechanisms that regulate brain function often emerge from extensive neural networks that work together to generate neural dynamics. These dynamics gain true meaning only when the collective activity of these circuits can be accurately captured.
That’s why we designed and developed high-density neural probes that, compared with any competing solution, provide the neuroscience community with an advanced electrophysiology tool capable of recording the bioelectrical activity of entire neural circuits with unmatched spatiotemporal resolution.
Multishanks recording
from 16 channels
Multishanks recoding
from 384 channels
SiNAPS
Multishanks recording
from 1024 channels
One technology, multiple layouts
Corticale probes are based on SiNAPS technology, which enables the development of active CMOS devices capable of recording simultaneously from all electrodes on the probe, while ensuring the following specifications:
256 simultaneously recording electrodes arranged in a two-column layoutSingle shankActive Area: 3865µm²
Model 1
1024 simultaneously recording electrodes arranged in a two-column layout
4 shanks with 560 µm inter-shank spacing
Active Area: 3865µm
²per shank
Model 2
512 simultaneously recording electrodes arranged in a two-column layout
Single shank
Active Area: 7750µm
²
Model 3
1024 simultaneously recording electrodes arranged in a two-column layout
8 shanks with 300µm inter-shank spacin
Active Area: 1925µm
²per shank
Model 4
512 simultaneously recording electrodes arranged in a four-column layout
Single shank
Active Area: 3870µm
²
Model 5
Hover a probe to see details.
The Corticale Ecosystem
SiNAPS probes are only as powerful as the workflow around them.
Corticale provides an end-to-end ecosystem: from in vivo data acquisition with our probes, through dedicated hardware, to analysis.
Voices from the field
" Understanding neural circuits is a problem of both depth and breadth, the SiNAPS probe provides true 1024 channels of simultaneous recording. With its configurable 4 or 8 shanks, it can record from a large volume of brain structures, such as the neocortex, hippocampus, striatum, and thalamus, allowing monitoring of both mesoscopic local field potentials and single neurons at an unprecedented scale. ”
-György Buzsáki, M.D., Ph.D., Biggs Professor of Neural Sciences at the NYU Neuroscience Institute, Langone Medical Center.
“These amazing probes give an unprecedented insight into cortical function. We have been able to record from many thousands of cells in awake behaving monkey, throughout the cortical depth and into the bank of the central sulcus. They are easy to use, and mark a considerable refinement because experimental sessions can be shortened whilst actually gathering more data. I especially appreciate the ability to record from all contacts at once, meaning we don’t have to make critical decisions on the fly about which channels to choose.”
-Stuart Baker, Professor of Movement Neuroscience
Faculty of Medical Sciences, Newcastle University
Our SiNAPS probes are compatible and provided by leading neurotech companies
SiNAPS probes data are compatible with most of the standard data analysis tools such as Kilosort, Phy and SpikeInterface.
Many laboratories around the world have already chosen to use our technology to advance their research
Progetto cofinanziato con risorse del PR FESR Liguria 2021/2027
Programma Regionale PR FESR Liguria 2021/2027 – Obiettivo Specifico 1.2. “Permettere ai cittadini, alle impese, alle organizzazioni di ricerca e alle autorità pubbliche di cogliere i vantaggi della digitalizzazione” – Azione 1.2.3 “Sostenere l’introduzione di pratiche e tecnologie digitali nelle imprese” – Bando “Supporto allo sviluppo di progetti di digitalizzazione nelle micro, piccole e medie imprese” – Anno 2024.
Via Pietro Chiesa 9
16149 Genova, Italy
Phone: +39 010 8595211
Email: info@corticale.com
Privacy Policy
Cookie Policy
Grants & Incentives
Quality Policy
Registered Office: Via Pietro Chiesa 9 - 16149 Genova (GE) | Branch: Via Porta Tenaglia 1 Milano (MI)
Progetto cofinanziato con risorse del PR FESR Liguria 2021/2027
Programma Regionale PR FESR Liguria 2021/2027 – Obiettivo Specifico 1.2. “Permettere ai cittadini, alle impese, alle organizzazioni di ricerca e alle autorità pubbliche di cogliere i vantaggi della digitalizzazione” – Azione 1.2.3 “Sostenere l’introduzione di pratiche e tecnologie digitali nelle imprese” – Bando “Supporto allo sviluppo di progetti di digitalizzazione nelle micro, piccole e medie imprese” – Anno 2024.
Via Pietro Chiesa 9
16149 Genova, Italy
Phone: +39 010 8595211
Email: info@corticale.com
Privacy Policy
Cookie Policy
Grants & Incentives
Quality Policy
Registered Office: Via Pietro Chiesa 9 - 16149 Genova (GE) | Branch: Via Porta Tenaglia 1 Milano (MI)
Progetto cofinanziato con risorse del PR FESR Liguria 2021/2027
Programma Regionale PR FESR Liguria 2021/2027 – Obiettivo Specifico 1.2. “Permettere ai cittadini, alle impese, alle organizzazioni di ricerca e alle autorità pubbliche di cogliere i vantaggi della digitalizzazione” – Azione 1.2.3 “Sostenere l’introduzione di pratiche e tecnologie digitali nelle imprese” – Bando “Supporto allo sviluppo di progetti di digitalizzazione nelle micro, piccole e medie imprese” – Anno 2024.
Via Pietro Chiesa 9
16149 Genova, Italy
Phone: +39 010 8595211
Email: info@corticale.com
Privacy Policy
Cookie Policy
Grants & Incentives
Quality Policy
Registered Office: Via Pietro Chiesa 9 - 16149 Genova (GE) Branch: Via Porta Tenaglia 1 Milano (MI)
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